{"id":8540,"date":"2019-07-19T10:55:55","date_gmt":"2019-07-19T08:55:55","guid":{"rendered":"https:\/\/gewebenetzwerk.de\/?page_id=8540"},"modified":"2026-01-05T12:57:44","modified_gmt":"2026-01-05T11:57:44","slug":"amnioclip-plus","status":"publish","type":"page","link":"https:\/\/gewebenetzwerk.de\/en\/amnioclip-plus\/","title":{"rendered":"AmnioClip-plus_eng"},"content":{"rendered":"<div  style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h1    avia-builder-el-0  el_before_av_one_half  avia-builder-el-first  '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >AmnioClip-plus for ophthalmology<\/h1><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding first  avia-builder-el-1  el_after_av_heading  el_before_av_one_half  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>The AmnioClip-plus (AC+) is used in ophthalmology to treat eye surface disorders, to preserve the eye, maintain or improve vision and it is useful for therapy of <em>dry eye<\/em> syndrome. AC+ can be applied in most situations where the use of amniotic membrane is common practice today, e.g.<\/p>\n<ul>\n<li>Persistent epithelial defects including neurotrophic corneal ulcers<br \/>\n(on host cornea\/corneal transplants)<\/li>\n<li>Reconstructions of conjunctival injuries<br \/>\n(e.g. burns or chemical burns, perforating trauma)<\/li>\n<li>Pterygium surgeries<\/li>\n<li>Symptomatic bullous keratopathy<\/li>\n<li>High-risk keratoplasty for limbal stem cell deficiency<\/li>\n<\/ul>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding   avia-builder-el-3  el_after_av_one_half  el_before_av_hr  \" style='border-radius:0px; '><div  class='avia-image-container  av-styling-    avia-builder-el-4  avia-builder-el-no-sibling  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img decoding=\"async\" class='wp-image-14040 avia-img-lazy-loading-not-14040 avia_image' src=\"https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AC-in-der-Gewebebank_web-1.jpg\" alt='' title='AC+ in der Gewebebank_web' height=\"867\" width=\"1300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AC-in-der-Gewebebank_web-1.jpg 1300w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AC-in-der-Gewebebank_web-1-600x400.jpg 600w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AC-in-der-Gewebebank_web-1-768x512.jpg 768w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AC-in-der-Gewebebank_web-1-1030x687.jpg 1030w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AC-in-der-Gewebebank_web-1-705x470.jpg 705w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AC-in-der-Gewebebank_web-1-450x300.jpg 450w\" sizes=\"(max-width: 1300px) 100vw, 1300px\" \/><\/div><\/div><\/div><\/div>\n<div  style='height:50px' class='hr hr-invisible   avia-builder-el-5  el_after_av_one_half  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>Advantages compared to conventional amniotic membrane transplantation (AMT)<\/h3>\n<p>With the AmnioClip-plus surgical trauma can be avoided in contrast to conventional AMT and suture-associated procedures. The treatment is repeatable and suitable for therapy of protracted\/chronic defects.<\/p>\n<\/div><\/section>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding first  avia-builder-el-7  el_after_av_textblock  el_before_av_one_half  column-top-margin\" style='border-radius:0px; '><div  class='avia-image-container  av-styling-    avia-builder-el-8  avia-builder-el-no-sibling  avia-align-center '  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img decoding=\"async\" class='wp-image-14043 avia-img-lazy-loading-not-14043 avia_image' src=\"https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AmnioClip_VS-web.jpg\" alt='' title='AmnioClip+_VS-web' height=\"900\" width=\"1300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AmnioClip_VS-web.jpg 1300w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AmnioClip_VS-web-600x415.jpg 600w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AmnioClip_VS-web-768x532.jpg 768w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AmnioClip_VS-web-1030x713.jpg 1030w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AmnioClip_VS-web-705x488.jpg 705w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/03\/AmnioClip_VS-web-450x312.jpg 450w\" sizes=\"(max-width: 1300px) 100vw, 1300px\" \/><\/div><\/div><\/div><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding   avia-builder-el-9  el_after_av_one_half  el_before_av_hr  column-top-margin\" style='border-radius:0px; '><div  class='avia-icon-list-container   avia-builder-el-10  avia-builder-el-no-sibling '><ul class='avia-icon-list avia-icon-list-left av-iconlist-big avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue816' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry av-iconlist-empty\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Easy to use<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue816' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry av-iconlist-empty\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Ambulant treatment<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue816' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry av-iconlist-empty\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Only local anesthesia necessary<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue816' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry av-iconlist-empty\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Minimal irritation<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue816' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry av-iconlist-empty\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><h4 class='av_iconlist_title iconlist_title   '  itemprop=\"headline\"  >Repeated treatment possible<\/h4><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/div>\n<div  style='height:50px' class='hr hr-invisible   avia-builder-el-11  el_after_av_one_half  el_before_av_one_full '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-12  el_after_av_hr  el_before_av_one_full  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>Manufacture and application<\/h3>\n<p>The medicinal product <em>AmnioClip-plus, cryopreserved, DGFG<\/em> has been approved by the Paul Ehrlich Institute (PEI) under the number PEI.G.11968.01.1. The amniotic membrane is clamped in the ring system in such a way that after application, the chorionic side lies on the surface of the eye to be treated. If desired, the reverse orientation can be ordered. The AC+ is inserted into the eye locally under drip anaesthesia. The size of the AC+ allows optimal positioning on the eye surface and prevents slippage. The treatment area should not exceed the size of the AC+. The AC+ can remain on the eye for up to 14 days. Repeated treatments are possible with a new AC+ for a further 14-day duration.<\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>Package leaflet<\/h3>\n<p>The AC+ is delivered deep-frozen in a sterile container and is individually customized for every procedure. If the AC+ is delivered on the morning of the operation, the transplant can remain in the transport box until approx. 30 minutes before use. A freezer is then not required.<\/p>\n<blockquote>\n<p>NEW: All amniotic preparations including the AmnioClip-plus can either be stored at below -60 \u00b0C for a maximum of 1 year from the date of manufacture or at -28 \u00b0C (+\/- 5 \u00b0C) for a maximum of 3 months from the start of storage.<\/p>\n<\/blockquote>\n<p>The AC+ <strong>must be used within 6 hours after thawing<\/strong> and <strong>must not be refrozen once thawing has begun<\/strong>. The <strong>maximum storage time<\/strong> (only if the AC+ has been transferred to a suitable freezer in the sterile container immediately after receipt and with continuous temperature monitoring) is <strong>1 year from the date of preparation at temperatures below -60\u00b0C<\/strong> (freezer or on dry ice) <strong>or at -28 \u00b0C (+\/- 5 \u00b0C) for a maximum of 3 months from the start of storage<\/strong>. The medicinal product is intended for single use only. The contents of a package are intended exclusively for use on a single patient.<\/p>\n<\/div><\/section><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>International allocation<\/h3>\n<p>A transfer of transplants to international locations is possible if the import is approved and all necessary documents are available. The tissue allocation office and the quality management of the DGFG will help with the clarification and implementation.<br \/>\nThe delivery time for orders outside Germany is dependent on the distance and country-specific requirements. The DGFG makes every effort to keep waiting times as short as possible. The DGFG charges an expense allowance for the provision of the transplants and the transport costs for the delivery. For increased flexibility, it is possible to store several AC+ on site in a suitable freezer.<\/p>\n<\/div><\/section><\/p><\/div>\n<div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-16  el_after_av_one_full  el_before_av_one_full  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>About the amnion<\/h3>\n<p>The amniotic membrane (AM) is the tissue surrounding the foetus in utero consisting of epithelium and stroma. AM can be easily extracted and preserved. Immunotolerance, promotion of epithelialisation, anti-inflammatory, anti-angiogenic, anti-fibroblastic and antimicrobial properties conferred characteristics of AM cells. The snap freezing of fresh samples during the production of AC+ preserves the desirable characteristics of the AM cells as compared to freeze dried sample collection methods. The AM is obtained from donors during planned Caesarean section. Consent is obtained from each donor after comprehensive donor evaluation and infection diagnostic analysis has been completed. The donated AM is processed in clean room conditions and subjected to extensive quality controls, including microbiological examinations.<\/p>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-18  el_after_av_one_full  el_before_av_one_third  column-top-margin\" style='border-radius:0px; '><article  class=\"iconbox iconbox_left    avia-builder-el-19  avia-builder-el-no-sibling  \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconbox_content\"><header class=\"entry-content-header\"><div class=\"iconbox_icon heading-color \" aria-hidden='true' data-av_icon='\ue81e' data-av_iconfont='entypo-fontello'  ><\/div><h3 class='iconbox_content_title  '  itemprop=\"headline\"  >Amniotic transplant safety<\/h3><\/header><div class='iconbox_content_container  '  itemprop=\"text\"  ><p>In Germany, tissue preparations are subject to the German Medicinal Products Act with its extensive approval and safety regulations. The German Society for Tissue Transplantation (DGFG) is approved for tissue preparation and transplantation in accordance with \u00a7 20 b and \u00a7 20 c of the German Medicinal Products Act. Each tissue donation is fully documented and traceable from consent to processing and transplantation.<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><\/div>\n<div class=\"flex_column av_one_third  flex_column_div av-zero-column-padding first  avia-builder-el-20  el_after_av_one_full  el_before_av_one_third  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center;\">Your contact persons<\/h3>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_third  flex_column_div av-zero-column-padding   avia-builder-el-22  el_after_av_one_third  el_before_av_one_third  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3 style=\"text-align: center;\">Literature<\/h3>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_third  flex_column_div av-zero-column-padding   avia-builder-el-24  el_after_av_one_third  el_before_av_one_third  column-top-margin\" style='border-radius:0px; '><\/div>\n<div class=\"flex_column av_one_third  flex_column_div av-zero-column-padding first  avia-builder-el-25  el_after_av_one_third  el_before_av_one_third  column-top-margin\" style='border-radius:0px; '><section  class='avia-team-member   avia-builder-el-26  avia-builder-el-no-sibling '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/Person\" ><div class='team-img-container'><img decoding=\"async\" width=\"591\" height=\"591\" class='wp-image-8875 avia-img-lazy-loading-not-8875 avia_image avia_image_team' src=\"https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/04\/Nicola-Hofmann3.jpg\" alt='Dr. rer. nat. Nicola Hofmann'  itemprop=\"image\" srcset=\"https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/04\/Nicola-Hofmann3.jpg 591w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/04\/Nicola-Hofmann3-80x80.jpg 80w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/04\/Nicola-Hofmann3-36x36.jpg 36w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/04\/Nicola-Hofmann3-180x180.jpg 180w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/04\/Nicola-Hofmann3-120x120.jpg 120w, https:\/\/gewebenetzwerk.de\/wp-content\/uploads\/2019\/04\/Nicola-Hofmann3-450x450.jpg 450w\" sizes=\"(max-width: 591px) 100vw, 591px\" \/><div class='team-social'><div class='team-social-inner'><span class='hidden av_member_url_markup '  itemprop=\"email\" >mailto:nicola.hofmann@gewebenetzwerk.de<\/span><a rel=\"v:url noopener\" target='_blank' class=' avia-team-icon ' href='mailto:nicola.hofmann@gewebenetzwerk.de' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/a><\/div><\/div><\/div><h3 class='team-member-name'    itemprop=\"name\" >Dr. rer. nat. Nicola Hofmann<\/h3><div class='team-member-job-title '   itemprop=\"jobTitle\" >Research &amp; Development<\/div><div class='team-member-description '  itemprop=\"description\"  ><p>Phone: +49 (0)511 - 563 559 366<\/p>\n<\/div><span class='hidden team-member-affiliation'  itemprop=\"affiliation\" >Deutsche Gesellschaft f\u00fcr Gewebetransplantation<\/span><\/section><\/div>\n<div class=\"flex_column av_one_third  flex_column_div av-zero-column-padding   avia-builder-el-27  el_after_av_one_third  el_before_av_one_third  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><ul>\n<li>Engelmann K, Kotomin I, Knipper A, Werner C. Nahtlose Amnionmembrantransplantation. Ophthalmologe. 18. Mai 2013;110(7):675\u201380.<\/li>\n<li>Kotomin I, Valtink M, Hofmann K, Frenzel A, Morawietz H, Werner C, u. a. Sutureless fixation ofamniotic membrane for therapy of ocular surface disorders. PLoS ONE. 2015;10(5):e0125035.<\/li>\n<\/ul>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_third  flex_column_div av-zero-column-padding   avia-builder-el-29  el_after_av_one_third  avia-builder-el-last  column-top-margin\" style='border-radius:0px; '><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8540","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AmnioClip-plus_eng - Deutsche Gesellschaft f\u00fcr Gewebetransplantation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gewebenetzwerk.de\/en\/amnioclip-plus\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AmnioClip-plus_eng - 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